Association of interleukin-10 -1082 A/G (rs1800896)polymorphism with susceptibility to gastric cancer:meta-analysis of 6,101 cases and 8,557 controls

ABSTRACT – Background – The promoter -1082 A/G (rs1800896) polymorphism of Interleukin-10 (IL-10) gene have been widely reported and considered to have a significant role on gastric cancer risk, but the results are inconsistent. Objective – To clarify the association, we conducted a meta-analysis to investigate the associations IL-10 -1082 A/G polymorphism with gastric cancer. Methods – Eligible articles were identified by searching databases including PubMed, Web of Science, and Google Scholar up to August 03, 2017. Odds ratios (OR) with corresponding 95% confidence intervals (CIs) were used to assess the association. Results – A total of 30 case-control studies with 6,101 cases and 8,557 controls were included in this meta-analysis. Overall, a significant association between IL-10 -1082 A/G polymorphism and gastric cancer risk was observed under the allele model (G vs A: OR=1.305, 95% CI=1.076-1.584; P=0.007), heterozygote model and (GA vs AA: OR=1.252, 95% CI=1.252-1.054; P=0.011) and dominant model (GG+GA vs AA: OR=1.264, 95% CI=1.053-1.516; P=0.012). In the subgroup analysis by ethnicity, increased gastric cancer risk were found in Asians under the allele model (G vs A: OR=1.520, 95% CI=1.172-1.973; P=0.002), homozygote model (GG+GA vs AA: OR=1.571, 95% CI=1.023- 2.414; P= 0.039), heterozygote model (GA vs AA: OR=1.465, 95% CI=1.192-1.801; P≤0.001) and dominant model (GG+GA vs AA: OR=1.448, 95% CI=1.152-1.821; P=0.002), but not among Caucasian and Latinos populations. Conclusion – These results suggested that the IL-10 -1082 A/G (rs1800896) polymorphism might contribute to the gastric cancer susceptibility, especially among Asians Author:Elnaz Foroughi, Rezavan Nasiri,Sodabeh Farahnak

Effects of Mustard Gas on Veterans: A Review

Introduction: Sulfur Mustard is an important field of research for Iranian scientists since 1983. This was from time that Iraq army used this chemical weapon against Iranians causing injury over more than 30,000 people still suffering from its late effects. Evidence Acquisition: This study has been collected from studies of searching online databases that have been studied in our review article. Results: Sulfur Mustard is synthesized by different methods, its exposure can cause severe, irreversible damage to skin, respiratory tract and eyes. In the eye, it has a wide spectrum effects. This effect begins with the asymptomatic period following irritation and redness and ends with damage to corneal structure with photophobia, temporary blindness and blepharospasm. Conclusion: Based on this here we are mentioning some of the attempts to better defined aspects .of Sulfur Mustard affects and mechanisms Author: Masoud Reza Gholi Zamenjani

Topical Application of the Hydroalcoholic Extract of Allium porrum L. as a Novel Treatment for Common Warts based on Persian Med

Abstract Background: Common warts are the infectious viral diseases that occur in the epidermal layer of skin and are transmitted through skin contact. They are caused by a diverse range of human papillomaviruses (HPV). So, there is no vaccine or definite anti-viral medication for the prevention of this disease. Also, the treatments of common warts often have some limitations and numerous side effects as well as the risk of recurrence or superficial spreading. Persian medicine is one of the oldest traditional medicines which described common warts as a kind of skin disease and recommended several herbal medicines like Allium porrum L. for the treatment of this disease. The aim of this study was to evaluate the effect of the hydroalcoholic extract of the aerial parts of Allium porrum L. on common warts. Methods: In this study, five patients with common warts on their hands were included. The hydroalcoholic extract of Allium porrum L. were applied on the site of the lesion just for 2 hours every day over a three-week period. The patients were followed up for 18 weeks to check any case of recurrence. Results: After completing the treatment, the wart lesions in all five patients were completely healed within three weeks. During the follow-up phase (18 weeks), no case of recurrence was observed. Conclusion: This study shows that the topical application of hydroalcoholic extract of Allium porrum L. has therapeutic effects for common warts. Since the extract is cost-effective, without complications and highly accepted by the patients, it seems that it can be further investigated in future studies

Effect of Hydroalcoholic Extract of Some Medicinal Plants on Obesity

چکیده انگلیسی Aims: Obesity is a significant cause of disability and death. This study was conducted to evaluate the efficacy of some medicinal plants in the treatment of obesity and its complications. Study Design: Male Wistar rats were treated in different groups. Place and Duration of Study: Department of Physiology, Arak University of Medical Sciences (Iran), December 2015 to July 2017. Methodology: The groups were defined as the control, the high-fat diet and the high-fat diet with hydroalcoholic extracts of Camellia sinensis, Rosa canina, Althaea officinalis, Plantago major and Orlistat in their food, for 48 days. In the serum, the profiles of the liver enzymes and the thyroid hormones were measured as parameters of their appetite. Results: The lowest increase in appetite happened in the Camellia sinensis group and the lowest levels of blood glucose and creatinine were in the Plantago primary group. The lowest cholesterol and low-density lipoprotein (LDL) were seen in the Camellia sinensis group (P<0.05). The amount of alanine aminotransferase (ALP) and the level of aspartate aminotransferase (AST) in the Plantago major group were significantly lower than the positive control group (P<0.05). In Althaea officinalis group were higher Orlistat and alkaline phosphatase (ALP) than the control group (P<0.05). The level of thyroid-stimulating hormone (TSH) in control group was significantly lower than the positive control, Camellia sinensis and Rosa canina groups (P<0.05). The level of thyroxin in Althaea officinalis, Rosa canina and Camellia sinensis groups were significantly lower than the positive control group, respectively (P<0.05). Conclusion: Hydroalcoholic extracts of Camellia sinensis, Rosa canina, Althaea officinalis, and Plantago major are effective in reducing the damages caused by high-fat diet through decreasing lipid profiles, liver enzymes, without causing side effects on thyroid and renal functions

Estimation of sexual behavior in the 18-to-24-years-old Iranian youth based on a crosswise model study

Abstract Background: In many countries, negative social attitude towards sensitive issues such as sexual behavior has resulted in false and invalid data concerning this issue. This is an analytical cross-sectional study, in which a total number of 1500 single students from universities of Shahroud City were sampled using a multi stage technique. The students were assured that their information disclosed for the researcher will be treated as private and confidential. The results were analyzed using crosswise model, Crosswise Regression, T-test and Chi-square tests. Findings: It seems that the prevalence of sexual behavior among Iranian youth is 41% (CI = 36-53). Conclusion: Findings showed that estimation sexual relationship in Iranian single youth is high. Thus, devising training models according to the Islamic-Iranian culture is necessary in order to prevent risky sexual behavior.

Determination of the Antimicrobial Effects of Hydro-Alcoholic Extract of Cannabis Sativa on Multiple Drug Resistant Bacteria Isolated from Nosocomial Infections

ABSTRACT Background: The science of identification and employment of medicinal plants dates back to the early days of man on earth. Cannabis (hashish) is the most common illegal substance used in the United States and was subjected to extensive research as a powerful local disinfecting agent for mouth cavity and skin and an anti-tubercular agent in 1950. Methods: Clinical strains were isolated from hospitalized patients in Vali-e-Asr Hospital of Arak. The hydro-alcoholic extract of cannabis (5 g) was prepared following liquid- liquid method and drying in 45˚C. The antimicrobial properties of the extract were determined through disk diffusion and determination of MIC (Minimum Inhibitory Concentration). Results: First, the sensitivity of bacteria was detected based on disk diffusion method and the zone of inhibition was obtained for MRSA (12 mm), S.aureus 25923 (14 mm), E. coli ESBL+: (10 mm), and Klebsiella pneumoniae (7 mm). Disk diffusion for Pseudomonas and Acinetobacter demonstrated no inhibitory zones. Through Broth dilution method, MIC of cannabis extract on the bacteria was determined: E.coli 25922: 50µg/ml, E.coli ESBL+:100 µg/ml, S.aureus 25923:25 µg/ml, MRSA: 50 µg/ml, Pseudomona aeroginosaESBL+> 100 µg/ml, Pseudomonas: 100 µg/ml, Klebsiella pneumoniae: 100 µg/ml, and Acinetobacter baumannii> 1000. Conclusion: The maximum anti-microbial effect of the hydro-alcoholic extract of cannabis was seen for gram positive cocci, especially S. aureus, whereas non- fermentative gram negatives presented resistance to the extract. This extract had intermediate effect on Enterobacteriacae family. Cannabis components extracted through chemical analysis can perhaps be effective in .treatment of nosocomial infections Hossein Sarmadyan, Hassan Solhi, Tahereh Hajimir, Negin Najarian-Araghi, Ehsanollah Ghaznavi-Rad

Fusion and development of 2-cell bovine embryos to tetraploid blastocyst with different voltages and durations

Abstract Background: The values of embryonic stem cell and cloning are evident. Production of clone from embryonic stem cells can be achieved by introduction of stem cell into a tetraploid blastocyst. Tetraploid blastocyst can be produced in vitro by electrofusion of 2-cell embryos. Objective: The aim of this study was to assess the effect of different voltages and durations on fusion rate of bovine 2-cell embryos and their subsequent development in vitro. Material and Methods: The in vitro produced bovine 2-cell embryos were categorized into 3 groups: (1) fused group (FG); 2-cell embryos fused by exposure to different voltages (0.5, 0.75, 1, 1.25 and 1.5 kV/cm) and durations (20, 40, 60, 80 and 100 μs), (2) exposed control group (ECG); 2-cell embryos exposed to different voltages and durations but remained unfused and (3) unexposed control group (UCG); embryos cultured without exposure to any voltage. The embryos from each group were cultured and fusion, cleavage and developmental rates were compared in each group. Results: The results show that increased voltage, increases the fusion rate up to 88% for 1.5 kV/cm; however, the rate of cleavage and blastocyst formation decreases significantly to 18% and 10% respectively (p<0.05). Increased duration does not significantly increase fusion rate, however, in high voltage, increased duration decreases cleavage rate and blastocyst formation rate. Blastocyst formation rate in UCG showed a better development (32%) compared to FG (20%) or ECG (22.5%) (p<0.05). Conclusion: It can be concluded that for optimal fusion, cleavage and development, one pulse of 0.75 kV/cm for 60μs should be applied.

Association of Sterile Pyuria and Coronary Artery Aneurysm in Kawasaki Syndrome

Abstract- Kawasaki disease (KD) is an inflammatory multiorgan disease of unknown etiology. The most dramatic organ involved is the heart. There were a few studies about cardiac involvement and sterile pyuria. This study guides to determine if sterile pyuria is associated with coronary artery aneurysm (CAA) in KD patients and to consider it as a predicting factor for coronary artery involvement. Forty seven patients with KD were studied by echocardiography in admission and one month later. Urine analysis, complete blood count, erythrocyte sedimentation rate and C-reactive protein were measured in admission. Data were analyzed using SPSS-14 software. Patients' age was ranged from 13 month to 7 years old (mean age of 3.43±1.54 years). Thirty patients (63.8%) were male and 17 patients (36.1%) were female. Cardiac involvement was detected in 32 patients (68%) using echocardiography, of which CAA was reported in 8 cases (17%). Six of CAA (75%) were in association with sterile pyuria, although it was statistically insignificant (P>0.05). Although the majority of patients with CAA had sterile pyuria, this association is not statistically significant, thus it couldn't be considered as a predicting factor for CAA.

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Increase 500 beds to Vali Asr Hospital beds

Governor General of Markazi province said that an increase of 500 beds to the total number of Vali Asr hospital beds is in the follow-up.